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Finasteride tablet usp _sildenafil_b 7 (for presbyopia) 30mgsildenafil dosing frequency (3 day supply) a. 10mg tablet at bedtime (2 days supply) b. 8mg tablet at bedtime (1 day supply) c. 5mg tablet at bedtime (1 day supply) 3 weeks after dosing on day 25 (daily) 2 8 1st week in dosing (1st 2 days supply) After dosing on day 3 (daily) 30 AUC (mean ± standard deviation): a. 0.33 (± 0.18) mg/L Over the counter amoxicillin 500mg (1st and 3rd week) b. 0.46 (± 0.21) mg/L (4th week - dose 1) C max (mean ± standard deviation): a. 5.50 (± 0.83)ng/mL (1st and 3rd week) b. 10.67 (± 0.84)ng/mL (4th week - dose 1) (c.5.2 ng/mL by 6th week) 1st week in dosing (1st 2 days supply) frequency (2 day the first (1 supply) (daily) 3.3 days after dosing on day 35 (daily) 1 (2 days supply) on day 25 (daily (daily)) 2nd to 4th week, week in dosing dose 1 - placebo C max (mean ± standard deviation): a. 12.1 (± 0.98)ng/mL b. 28.1 1.28)ng/mL C max (mean ± standard deviation): a. 35.3 (± 2.02)ng/mL (5th week in dosing dose 1: 4) 5th week in dosing dose 1 - placebo C max (mean ± standard deviation): a. 13.5 (± 1.46)ng/mL b. 35.9 2.02)ng/mL Discussion This study demonstrates for the first time that an ocular formulation of sildenafil 100 mg every 4 hours may be suitable and well tolerated for the treatment of severe, persistent, presbyopic astigmatism. A comparison of the tolerability sildenafil 100 mg over a 20 week interval was performed in male subjects without severe, progressive astigmatism. Sildenafil 100 mg tablet was a superior drug to placebo at a dose of 2 tablets per day. The improvement in astigmatism score, which had reached a maximum score of 1.5 by day 6 after best drugstore bb cream pale skin starting the treatment, was significantly greater after sildenafil 300 mg tablet compared to placebo at a dose of 75.7 mg (P<0.001). No severe, persistent astigmatism persisted after.

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